An estimated 5,000 cycles of PGD/PGS are being performed in the United States each year. Although the use of these techniques has increased over the past decade, the number of PGD/PGS cycles continues to represent only a small fraction of the more than 100,000 IVF procedures performed annually in the United States alone. The rate of congenital anomalies and of pregnancy complications following PGD/PGS does not appear to be increased over the baseline measurements.

On occasion, misdiagnosis may occur, so patients undergoing PGD/PGS are usually offered traditional prenatal diagnostic tests (chorionic villus sampling-CVS or amniocentesis) to confirm the results. The rates of misdiagnosis in PGD range from 1% to 9%. Embryos from which no diagnostic information is obtained are usually discarded rather than risk embryo transfer, although this policy varies from clinic to clinic. The other risks of PGD/PGS are the same as those associated with any cycle of IVF, including multiple pregnancy and OHSS.