The Sperm Chromatin Structure Assay (SCSA) has been proposed as a means to predict the likelihood of pregnancy in cases of male factor infertility. This test analyzes the degree of DNA fragmentation present in a representative sample of sperm. Increased levels of DNA fragmentation seem to be associated with reduced pregnancy rates, including poorer treatment outcomes with IVF and ICSI. There is no level of fragmentation above which pregnancy is completely ruled out, however, so the SCSA cannot ultimately provide a means to absolutely recommend the use of donor sperm over the sperm from the male partner. If a couple is making a choice between the use of donor sperm compared with partner sperm, then the SCSA may provide a relative indication to use the donor sperm option. At this time, most experts consider this test to be experimental.