In general, one well-timed IUI is as good as two, and no advantage is obtained by performing a second IUI (providing ovulation was well monitored using blood hormone determinations and follicle ultrasound measurements). However, in patients who are undergoing IUI with less intense monitoring of ovulation, such as urine LH testing, or for those women who chose not to monitor their ovulation at all, two inseminations may be a better option.

Using basal body temperatures as the basis for an IUI’s timing is not recommended, because this method cannot prospectively pinpoint the optimal timing of ovulation for an IUI treatment. The rise in basal body temperature occurs after ovulation, so identifying this temperature increase would not help in scheduling an IUI procedure.